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One of the reasons we love AOD 9604 is that clinical trials have shown it to be very well-tolerated, with no significant impact on blood sugar, insulin levels, or IGF-1
Clinical trials back this up: the STEP trials showed an average weight reduction of around 15% with Semaglutide, while the SURMOUNT trials reported up to 20% with Tirzepatide
"L-carnitine treatment of insulin resistance: A systematic review and meta-analysis." National Library of Medicine
As shown in Figure 4F , the transcriptional levels of IL-21 and IFNG in the L-Cn-treated groups were significantly lower than those in the control groups in both Jersey and Holstein cattle, which were consistent with the results of the available in vitro experiments, while the transcripts encoding immunosuppressive profiles, such as myeloid-derived suppressor cells ( CD33 ), arginase-1 ( Arg1 ), and inhibitory receptors ( PD-L1 , CTLA4 , and HAVCR2 ) were higher in the L-Cn-treated groups
